A METHOD OF PRODUCING A CRYSTALLINE FORM OF SODIUM 2-[(4S)-8-FLUORO-2-[4-(3-METHOXYPHENYL)PIPERAZIN-1-YL]-3-[2-MET HOXY-5-(TRIFLUOROMETHYL)PHENYL]-4H-QUINAZOLIN-4-YL]ACETATE TRIHYDRATE

A METHOD OF PRODUCING A CRYSTALLINE FORM OF SODIUM 2-[(4S)-8-FLUORO-2-[4-(3-METHOXYPHENYL)PIPERAZIN-1-YL]-3-[2-MET HOXY-5-(TRIFLUOROMETHYL)PHENYL]-4H-QUINAZOLIN-4-YL]ACETATE TRIHYDRATE

The present invention refers to an effective method of preparing a crystalline form of 2- [(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-metho xy-5- (trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid sodium trihydrate. La presente invención se refiere a un método eficaz para preparar...

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Hauptverfasser: CERON BERTRAN Jordi Carles, GOLDNER Thomas, BUSCHMANN Helmut
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention refers to an effective method of preparing a crystalline form of 2- [(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-metho xy-5- (trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid sodium trihydrate. La presente invención se refiere a un método eficaz para preparar una forma cristalina de trihidrato de sodio del ácido 2-[(4S)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi- 5-(trifluorometil)fenil]-4H-quinazolin-4-il]acético.