METHOD FOR OBTAINING ALPHA-1 PROTEINASE INHIBITOR

Methods for obtaining highly-concentrated Alpha- 1 Proteinase Inhibitor (A1 PI) comprising a step of preparing a solution of A1 PI by concentrating an initial solution of A1 PI by tangential flow filtration (TFF) against water wherein the final concentration of A1 PI in the concentrated solution is...

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Bibliographische Detailangaben
Hauptverfasser:	GRADY George, REBBEOR James, MCBRIDE Dennis, A YUZIUK Jeffrey
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION TRANSPORTING
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Beschreibung
Zusammenfassung:	Methods for obtaining highly-concentrated Alpha- 1 Proteinase Inhibitor (A1 PI) comprising a step of preparing a solution of A1 PI by concentrating an initial solution of A1 PI by tangential flow filtration (TFF) against water wherein the final concentration of A1 PI in the concentrated solution is at least 110 mg/ml. Procedimientos para obtener un inhibidor de proteinasa alfa-1 (A1PI) altamente concentrado que comprende una etapa de preparar una solución de A1PI concentrando una solución inicial de A1PI mediante filtración de flujo tangencial (TFF) contra agua, en el que la concentración final de A1PI en la solución concentrada es, como mínimo, 110 mg/ml.