METHODS FOR DOSING AND TREATMENT OF FOLLICULAR LYMPHOMA AND MARGINAL ZONE LYMPHOMA IN ADOPTIVE CELL THERAPY

Provided herein are methods of administering a dose of T cells for treating subjects with indolent non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. The cells express a recombinant receptor such as a chimeric antigen receptor (CAR) for targeting an antigen of the lymphoma, such as CD19. In some embodiments, the methods are for treating grade 1-3 A follicular lymphoma (FL 1-3 A) or marginal zone lymphoma (MZL), including in heavily pretreated or poor-prognosis subjects, such as subjects that have relapsed after treatment with, or are refractory to treatment with, one or more prior therapies. En la presente se proporcionan métodos para administrar una dosis de células T para tratar sujetos con linfoma no de Hodgkin (LNH) indolente, y métodos, composiciones, usos y artículos de fabricación relacionados. Las células expresan un receptor recombinante tal como un receptor de antígeno quimérico (CAR) para dirigirse a un antígeno del linfoma, tal como CD19. En algunas modalidades, los métodos son para tratar linfoma folicular de grado 1-3A (FL 1- 3A) o linfoma de zona marginal (MZL), incluidos sujetos intensamente pretratados o de mal prognosis, tal como sujetos que han recaído después del tratamiento con, o son refractarios al tratamiento con, una o más terapias previas.