COMBINATION THERAPIES FOR TREATING CANCER

Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRPÎ± D1 domain variant and an Fe domain variant in combination with at least one chemotherapy agent and/or at least one therapeutic antibody. Also provided are related kit...

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Bibliographische Detailangaben
Hauptverfasser:	WAN Hong, PONS Jaume, SIM Bang Janet, KUO Tracy, Chia- Chien, RANDOLPH Sophia
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRPÎ± D1 domain variant and an Fe domain variant in combination with at least one chemotherapy agent and/or at least one therapeutic antibody. Also provided are related kits. Se proporcionan métodos para el tratamiento del cáncer que comprenden administrar un polipéptido (p. ej., un polipéptido de fusión) que comprende una variante del dominio D1 de SIRPa y una variante del dominio Fc en combinación con al menos un agente quimioterapéutico y/o al menos un anticuerpo terapéutico. También se proporcionan kits relacionados.