5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY

The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cy...

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Bibliographische Detailangaben
Hauptverfasser:	THURAIRATNAM Sukanthini, YEOMAN Helen, HARTUNG Ryan, GAO Zhongli, SMRCINA Martin, MA Nina, MECHIN Ingrid, WIRE William, HURLBUT Gregory, FREED Brian, NESTLER Hans Peter, LEBRETON Sylvain, VIVET Bertrand, LIAO Junkai, BALTZER Sylvie, MUNSON Mark
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis. La invención está relacionada con compuestos de heteroarilo, sales farmacéuticamente aceptables de los mismos, y preparaciones farmacéuticas de los mismos. En la presente también se describen composiciones y el uso de esos compuestos en métodos de tratamiento de enfermedades y afecciones mediadas por la deficiencia de la actividad del CFTR, en particular la fibrosis quística.