ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF

ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF

The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases. La descripción s...

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Bibliographische Detailangaben
Hauptverfasser: SCOTT David A, GRAY Nathanael S, ECK Michael, HEPPNER David, BEYETT Tyler, HUANG Shih- Chung, HU Yongbo, TO Ciric, STROUD Steve, GERO Thomas, CULLIS Courtney A
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases. La descripción se refiere a compuestos que actúan como inhibidores alostéricos del receptor de factor de crecimiento epidérmico (EGFR); composiciones farmacéuticas y comprenden los compuestos; y métodos para tratar o prevenir trastornos mediados por cinasa, incluido cáncer y otras enfermedades de proliferación.