SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE

Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the co...

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Bibliographische Detailangaben
Hauptverfasser:	CHE Jianwei, ZHANG Tinghu, LIU Hu, GRAY Nathanael S, JONES Lyn Howard
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation. Se divulgan compuestos y sales, hidratos, solvatos, profármacos, estereoisómeros o tautómeros farmacéuticamente aceptables de los mismos que pueden provocar la degradación de diversas proteínas, por ejemplo, IKZF2 (Helios). También se divulgan composiciones farmacéuticas que los contienen y los procedimientos de producción y de uso de los compuestos para tratar enfermedades y trastornos asociados con Helios y que pueden beneficiarse de la degradación de Helios.