TREATMENT AND PREVENTION OF CANCER USING HER3 ANTIGEN-BINDING MOLECULES

Methods for treating or preventing a cancer in a subject are disclosed, wherein the cancer comprises cells having a mutation resulting in increased expression of a ligand for HER3, wherein the method comprises administering a therapeutically or prophylactically effective amount of an antigen-binding...

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Bibliographische Detailangaben
Hauptverfasser:	BOYD-KIRKUP Jerome Douglas, SANCENON Vicente, WU Zhihao, GUAN Siyu, PASZKIEWICZ Konrad, INGRAM Piers, THAKKAR Dipti
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Methods for treating or preventing a cancer in a subject are disclosed, wherein the cancer comprises cells having a mutation resulting in increased expression of a ligand for HER3, wherein the method comprises administering a therapeutically or prophylactically effective amount of an antigen-binding molecule which is capable of binding to HER3 to the subject. Se describen métodos para tratar o prevenir un cáncer en un sujeto, en donde el cáncer comprende células que tienen una mutación que da como resultado un aumento en la expresión de un ligando para HER3, en donde el método comprende administrar una cantidad terapéutica o profilácticamente eficaz de una molécula de unión a antígeno que es capaz de unirse a HER3 al sujeto.