COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS

The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/ or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination...

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Bibliographische Detailangaben
Hauptverfasser: LAM Imelda, SULLIVAN Robert, ERDMAN Paul E, CHOURASIA Aparajita Hoskote, FUNG Leah, HECHT David Aaron, MERCURIO Frank, CHAN Kyle W. H, TORRES Eduardo
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/ or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided. La presente descripción provee compuestos, por ejemplo, un compuesto de Fórmula (I), que modula la función de una proteína y/o restaura la homeostasis de la proteína. La descripción provee un método para modular una enfermedad, trastorno, afección o respuesta mediada por proteínas. Se proveen composiciones, incluso en combinación con otros agentes terapéuticos.