DELIVERY OF ONCOLYTIC VIRUSES USING DENDRITIC CELLS

A versatile carrier system for systemic delivery of oncolytic viruses comprises dendritic cells having at least one oncolytic virus loaded therein. It is believed that the dendritic cells will protect the oncolytic virus(es) against neutralizing antibodies, can transport the oncolytic virus(es) to t...

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Bibliographische Detailangaben
Hauptverfasser:	TARAROVA Natalia D, CHUMAKOV Peter M, CHUMAKOV Stepan P, LIPATOVA Anastasia V, BERZHITSKAYA Darya A, CHARLES Stephen A, KOMAR Anton A
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A versatile carrier system for systemic delivery of oncolytic viruses comprises dendritic cells having at least one oncolytic virus loaded therein. It is believed that the dendritic cells will protect the oncolytic virus(es) against neutralizing antibodies, can transport the oncolytic virus(es) to targeted tumor locations, and then deliver virions to the tumor locations. Un sistema portador versátil para la entrega sistémica de virus oncolíticos que comprende células dendríticas que tienen al menos un virus oncolítico cargado en ellas. Se cree que las células dendríticas protegerán el(los) virus oncolíticos contra anticuerpos neutralizantes, pueden transportar el(los) virus oncolíticos a las ubicaciones de los tumores específicos y luego entregar los viriones a las ubicaciones de los tumores.