ENHANCED PERFORMANCE OF AMORPHOUS SOLID AND SOLUBILIZED FORMULATIONS FOR ACHIEVING THERAPEUTIC PLASMA CONCENTRATIONS

This invention relates to solid amorphous Compound (I) having the formula (I) and to solid amorphous dispersions comprising Compound (I) and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stabili...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	GARMISE Robert J, ZIEMBA Theresa M, SAXENA Ajay, LEVONS Jaquan Kalani, STEFANSKI Kevin J, WAKNIS Vrushali M, REDDY Jay Poorna, SRIDHAR Srikanth Koravady, CHOWAN Gajendra Singh, NARASIMHAMURTHY Roopa, PATTASSERI Shabeerali, PAL Sharmistha, PANDURANGA Narayan Swamy
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This invention relates to solid amorphous Compound (I) having the formula (I) and to solid amorphous dispersions comprising Compound (I) and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stability and bioavailability. This invention relates to solid amorphous dispersions comprising Compound (I) having the formula (I) and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stability and bioavailability. Esta invención se refiere a un compuesto sólido amorfo (I) que tiene la fórmula (I) y a dispersiones sólidas amorfas que comprenden el compuesto (I) y uno o más polímeros o a formulaciones en solución que comprenden el compuesto (I) y uno o más codisolventes y tensioactivos. Las formulaciones exhiben una estabilidad y biodisponibilidad mejoradas. Esta invención se refiere a dispersiones sólidas amorfas que comprenden el compuesto (I) que tiene la fórmula (I) y uno o más polímeros o a formulaciones en solución que comprenden el compuesto (I) y uno o más codisolventes y tensioactivos. Las formulaciones exhiben una estabilidad y biodisponibilidad mejoradas.