ANTI-INTEGRIN ANTIBODIES AND USES THEREOF

ANTI-INTEGRIN ANTIBODIES AND USES THEREOF

Anti-integrin antibodies are disclosed. Also disclosed are methods of using the antibodies to treat or prevent disorders such as fibrotic diseases, cancer, ophthalmology disorders, and NAFLD. Further disclosed are methods of selecting an antibody that specifically binds to ανβΐ, or that binds to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GARDET Agnes, MULLEN Tracey, GRAFF Christilyn, BLAKELEY Brett, PALMER Christina
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Anti-integrin antibodies are disclosed. Also disclosed are methods of using the antibodies to treat or prevent disorders such as fibrotic diseases, cancer, ophthalmology disorders, and NAFLD. Further disclosed are methods of selecting an antibody that specifically binds to ανβΐ, or that binds to ανβΐ and ανβό, or that binds to one or more members of the RGD sub-family of integrins. Se describen anticuerpos antiintegrina. También se describen métodos de uso de los anticuerpos para tratar o prevenir trastornos tales como enfermedades fibróticas, cáncer, trastornos oftalmológicos y NAFLD. Se describen además métodos para seleccionar un anticuerpo que se une específicamente a avß1, o que se une a avß1 y avß6, o que se une a uno o más miembros de la subfamilia de integrinas RGD.