1-((2-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-4-YL)METHYL)UREA DERIVATIVES AS KCNQ POTENTIATORS

Small molecule potentiatiors to potassium channels (such as Kv7 potentiators â which are also called KCNQ potentiators), compositions including such compounds, and methods of using such compounds for the treatment of Amyotrophic Lateral Sclerosis and other neurological diseases caused by changes in...

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Bibliographische Detailangaben
Hauptverfasser:	WILLIAMS Andrew Caerwyn, SZEKERES Helen Jane, WHATTON Maria Ann
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Small molecule potentiatiors to potassium channels (such as Kv7 potentiators â which are also called KCNQ potentiators), compositions including such compounds, and methods of using such compounds for the treatment of Amyotrophic Lateral Sclerosis and other neurological diseases caused by changes in motor neuron excitability, including, but not limited to, primary lateral sclerosis, pseudobulbar palsy, progressive bulbar palsy, progressive muscular atrophy and epilepsy. Potenciadores de molécula pequeña de canales de potasio (tales como los potenciadores de Kv7-que son llamados también potenciadores de KCNQ), composiciones que incluyen tales compuestos y métodos para usar tales compuestos para el tratamiento de Esclerosis Lateral Amiotrófica y otras enfermedades neurológicas causadas por cambios en la excitabilidad de neuronas motoras, que incluyen, entre otras, esclerosis lateral primaria, parálisis pseudobulbar, parálisis bulbar progresiva, atrofia muscular progresiva y epilepsia.