ANTI-IL-36 ANTIBODIES AND METHODS OF USE THEREOF

ANTI-IL-36 ANTIBODIES AND METHODS OF USE THEREOF

The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36α, IL-36β, and/or IL-36γ, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of makin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KARRER Erik Edward, PATEL Ashka, THAI Tina, FUH-KELLY Germaine, BHARILL Shashank, SCHARF Louise, LEE Chingwei Vivian
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36α, IL-36β, and/or IL-36γ, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided. La presente invención proporciona proteínas de unión, tales como anticuerpos y fragmentos de unión a antígeno, que se unen específicamente a citocinas IL-36 humanas, IL-36a, IL-36ß y/o IL-36?, y bloquean las rutas de señalización estimuladas por IL-36. También se proporcionan composiciones que comprenden dichas proteínas de unión y procedimientos para prepararlas y usarlas.