RAPAMYCIN DERIVATIVES

The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	BONAZZI Simone, CONNOLLY Michael, MIHALIC Manuel, ROGGO Silvio, SHAVLAKADZE Tea, PATTERSON Andrew W, ZUEGER Patrik, GLASS David J
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof for treating the diseases and disorders described herein. La invención proporciona derivados de 32-desoxo-rapamicina de la Fórmula (I) (ver Fórmula) (I), o una sal farmacéuticamente aceptable de los mismos, composiciones farmacéuticas y combinaciones farmacéuticas que comprenden un compuesto de la Fórmula (I), y métodos de elaboración de las mismas. También se proporcionan métodos de uso de un compuesto de la fórmula (I) o una sal farmacéuticamente aceptable del mismo para tratar las enfermedades y trastornos descriptos en la presente.