PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)

PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)

Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for examp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HELM Matthew Duncan, ROZYCKA Ewelina, CRANSTON Aaron, BURKAMP Frank, SHEPHERD Steven David, WHITEHEAD Steven Kristopher, JACQ Xavier, PROCTOR Lauren Emma, ROUNTREE James Samuel Shane, HARRISON Timothy, TREDER Adam Piotr, COSTA Joana Rita Castro, O'DOWD Colin
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy. Se proporcionan inhibidores de la USP19, métodos para tratar la obesidad, síndrome metabólico y/o diabetes usando los compuestos inhibidores de la USP19, así como aquellos compuestos para usarse en métodos para tratar la obesidad, el síndrome metabólico y/o la diabetes. También se proporcionan métodos para tratar la atrofia muscular, por ejemplo, caquexia o sarcopenia con compuestos inhibidores de la USP19, además de aquellos compuestos para usarse en métodos para tratar la atrofia muscular.