C11-CYCLIC SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF

C11-CYCLIC SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF

Provided are 13-membered macrolides for the treatment of infectious diseases. The 13- membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13- membered macrolides, and methods of treating...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CARLSEN Peter Niels, CLARK Roger B, AUSTIN Wesley Francis, ALM Richard, SHI Shuhao, ZHANG Ziyang, WANG Wenying, MYERS Andrew G, LAWRENCE Jonathan F, RAHMAN Md. Ataur, LAHIRI Sushmita D, JEWETT Ivan, LI Xiben, ICHIKAWA Yoshitaka, GONDI Vijaya, HOGAN Philip
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Provided are 13-membered macrolides for the treatment of infectious diseases. The 13- membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13- membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides. Se proporcionan macrólidos de 13 miembros para el tratamiento de enfermedades infecciosas. Los macrólidos de 13 miembros descritos en este documento son azacetólidos. También se proporcionan métodos para preparar los macrólidos de 13 miembros, composiciones farmacéuticas que comprenden los macrólidos de 13 miembros y métodos para tratar enfermedades infecciosas y, en particular, enfermedades resultantes de bacterias gramnegativas usando los macrólidos descritos.