ARYLSULFONYLPYROLECARBOXAMIDE DERIVATIVES AS KV3 POTASSIUM CHANNEL ACTIVATORS

The present invention provides novel compounds which activate the Kv3 potassium channels. The compounds have the structure (Formula I), Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and use of the compounds to treat disorders responsive to th...

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Bibliographische Detailangaben
Hauptverfasser:	YU Wanwan, RASMUSSEN Lars Kyhn, FLEMING Paul Robert, SAMS Anette Graven
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides novel compounds which activate the Kv3 potassium channels. The compounds have the structure (Formula I), Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and use of the compounds to treat disorders responsive to the activation of Kv3 potassium channels. La presente invención proporciona compuestos novedosos que activan los canales de potasio Kv3. Los compuestos tienen la estructura (Fórmula I), (ver Fórmula) Aspectos separados de la invención se refieren a composiciones farmacéuticas que comprenden dichos compuestos y el uso de los compuestos para tratar trastornos que responden a la activación de los canales de potasio Kv3.