MESOTHELIN AND CD137 BINDING MOLECULES
The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the tr...
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creator | TUNA Mihriban WOLLERTON Francisca FERTIN Remi READER Claire BREWIS Neil MUNOZ-OLAYA Jose |
description | The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the treatment of cancer, for example.
La presente invención se refiere a moléculas de anticuerpo que se unen tanto a mesotelina (MSLN) como a CD137. Las moléculas de anticuerpo comprenden un sitio de unión basado en CDR para MSLN, y un sitio de unión al antígeno CD137 ubicado en un dominio constante de la molécula de anticuerpo. Las moléculas de anticuerpo encuentran aplicación en el tratamiento del cáncer, por ejemplo. |
format | Patent |
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La presente invención se refiere a moléculas de anticuerpo que se unen tanto a mesotelina (MSLN) como a CD137. Las moléculas de anticuerpo comprenden un sitio de unión basado en CDR para MSLN, y un sitio de unión al antígeno CD137 ubicado en un dominio constante de la molécula de anticuerpo. Las moléculas de anticuerpo encuentran aplicación en el tratamiento del cáncer, por ejemplo.</description><language>eng ; spa</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210527&DB=EPODOC&CC=MX&NR=2021000397A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210527&DB=EPODOC&CC=MX&NR=2021000397A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TUNA Mihriban</creatorcontrib><creatorcontrib>WOLLERTON Francisca</creatorcontrib><creatorcontrib>FERTIN Remi</creatorcontrib><creatorcontrib>READER Claire</creatorcontrib><creatorcontrib>BREWIS Neil</creatorcontrib><creatorcontrib>MUNOZ-OLAYA Jose</creatorcontrib><title>MESOTHELIN AND CD137 BINDING MOLECULES</title><description>The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the treatment of cancer, for example.
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La presente invención se refiere a moléculas de anticuerpo que se unen tanto a mesotelina (MSLN) como a CD137. Las moléculas de anticuerpo comprenden un sitio de unión basado en CDR para MSLN, y un sitio de unión al antígeno CD137 ubicado en un dominio constante de la molécula de anticuerpo. Las moléculas de anticuerpo encuentran aplicación en el tratamiento del cáncer, por ejemplo.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | MESOTHELIN AND CD137 BINDING MOLECULES |
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