MESOTHELIN AND CD137 BINDING MOLECULES

The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the tr...

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Hauptverfasser: TUNA Mihriban, WOLLERTON Francisca, FERTIN Remi, READER Claire, BREWIS Neil, MUNOZ-OLAYA Jose
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creator TUNA Mihriban
WOLLERTON Francisca
FERTIN Remi
READER Claire
BREWIS Neil
MUNOZ-OLAYA Jose
description The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the treatment of cancer, for example. La presente invención se refiere a moléculas de anticuerpo que se unen tanto a mesotelina (MSLN) como a CD137. Las moléculas de anticuerpo comprenden un sitio de unión basado en CDR para MSLN, y un sitio de unión al antígeno CD137 ubicado en un dominio constante de la molécula de anticuerpo. Las moléculas de anticuerpo encuentran aplicación en el tratamiento del cáncer, por ejemplo.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title MESOTHELIN AND CD137 BINDING MOLECULES
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