MESOTHELIN AND CD137 BINDING MOLECULES

MESOTHELIN AND CD137 BINDING MOLECULES

The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the tr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TUNA Mihriban, WOLLERTON Francisca, FERTIN Remi, READER Claire, BREWIS Neil, MUNOZ-OLAYA Jose
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the treatment of cancer, for example. La presente invención se refiere a moléculas de anticuerpo que se unen tanto a mesotelina (MSLN) como a CD137. Las moléculas de anticuerpo comprenden un sitio de unión basado en CDR para MSLN, y un sitio de unión al antígeno CD137 ubicado en un dominio constante de la molécula de anticuerpo. Las moléculas de anticuerpo encuentran aplicación en el tratamiento del cáncer, por ejemplo.