SCAFFOLD PROTEIN FOR GENERATING CHIMERIC ANTIGEN-BINDING PROTEINS

The present invention relates to a scaffold protein of SEQ ID NO: 1 derived from a conotoxin, which does not have amino acid residues associated with the toxic activity of the conotoxin and is useful for generating chimeric proteins of up 19 to 47 amino acids, inserting between its amino acids 11 an...

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Bibliographische Detailangaben
Hauptverfasser:	LICEA NAVARRO Alexei Fedorovish, SÁNCHEZ CAMPOS Liliana Noemí, DUEÑAS ESPINOZA Salvador
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to a scaffold protein of SEQ ID NO: 1 derived from a conotoxin, which does not have amino acid residues associated with the toxic activity of the conotoxin and is useful for generating chimeric proteins of up 19 to 47 amino acids, inserting between its amino acids 11 and 12 fragments of a CDR3 of a vNAR with an affinity for a specific antigen. Una proteína de andamio de SEQ ID NO: 1 derivada de una conotoxina, que no presenta residuos de aminoácidos asociados a la actividad tóxica de la conotoxina, y que puede ser usada para la generación de proteínas quiméricas de entre 19 a 47 aminoácidos, insertándole entre sus aminoácidos 11 y 12, fragmentos de un CDR3 de un vNAR con afinidad por un antígeno específico.