METHOD FOR THE SAFE INDUCTION OF IMMUNITY AGAINST RSV

The present invention relates to methods of inducing a safe immune response against respiratory syncytial virus (RSV) in a human subject in need thereof, comprising administering to the subject a composition comprising recombinant adenovirus comprising nucleic acid encoding an RSV Fusion (F) protein...

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Bibliographische Detailangaben
Hauptverfasser:	WILLIAMS Kristi Lynn, WIDJOJOATMODJO Myra Noorely, C S CALLENDRET Benoit, GODEAUX Olivier, SADOFF Jerald
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to methods of inducing a safe immune response against respiratory syncytial virus (RSV) in a human subject in need thereof, comprising administering to the subject a composition comprising recombinant adenovirus comprising nucleic acid encoding an RSV Fusion (F) protein comprising the amino acid sequence of SEQ ID NO: 1, and a pharmaceutically acceptable carrier, in a total dose of from about 1x1010 to about 2x10 11 viral particles (vp). La presente invención se refiere a métodos para inducir una respuesta inmune segura contra el virus sincitial respiratorio (VSR) en un sujeto humano que lo necesita, que comprenden administrar al sujeto una composición que comprende un adenovirus recombinante que comprende ácido nucleico que codifica una proteína de fusión (F) del RSV que comprende el secuencia de aminoácidos de SEQ ID NO: 1, y un vehículo farmacéuticamente aceptable, en una dosis total de aproximadamente 1x1010 a aproximadamente 2x1011 partículas virales (vp).