NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compoun...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Abraham THOMAS, Malini BAJPAI, Rajendra Laxman HARDE, Neelima KHAIRATKAR-JOSHI, Shailesh Ramesh PARDESHI, Sanjib DAS, Daisy Manish SHAH, Sandeep Yadunath SHELKE, Laxmikant Atmaram GHARAT
Format: Patent
Sprache:eng ; spa
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer. La presente descripción se dirige a compuestos de fórmula (I) y sales farmacéuticamente aceptables de estos donde el anillo A, el anillo B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p y q son como se definen en la presente, que se activan como moduladores del receptor huérfano gamma t asociado con retinoides (ROR?t). Estos compuestos evitan, inhiben o suprimen la acción de ROR?t y, por lo tanto, son útiles en el tratamiento de enfermedades, trastornos, síndromes o afecciones mediadas por ROR?t tales como, por ejemplo, dolor, inflamación, COPD, asma, artritis reumatoide, colitis, esclerosis múltiple, soriasis, enfermedades neurodegenerativas y cáncer.