THERAPEUTIC ANTIBODIES BASED ON MUTATED IGG HEXAMERS

THERAPEUTIC ANTIBODIES BASED ON MUTATED IGG HEXAMERS

The present invention relates to formulation of antibodies. The invention relates in particular to pharmaceutical compositions comprising an antibody molecule of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding. La prese...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Andrew HAGARMAN, Mette Hamborg JENSEN, Cale HALBLEIB, Lene Schantz HARLOW
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to formulation of antibodies. The invention relates in particular to pharmaceutical compositions comprising an antibody molecule of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding. La presente invención se refiere a una formulación de anticuerpos. La invención se refiere en particular a composiciones farmacéuticas que comprenden una molécula de anticuerpo del isotipo IgG1 que tiene una mutación en la región Fc que mejora el agrupamiento de moléculas IgG después de la unión a antígeno de superficie celular.