ENGINEERED NATURAL KILLER CELLS AND USES THEREOF

Provided herein are engineered natural killer cells that have been modified to express chimeric antigen receptors (CARs). The cells optionally contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites. Also contemplated are methods for using the engineered natura...

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Bibliographische Detailangaben
1. Verfasser:	Michael Eamon Peter O''DWYER
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are engineered natural killer cells that have been modified to express chimeric antigen receptors (CARs). The cells optionally contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites. Also contemplated are methods for using the engineered natural killer cells to treat patients with cancer. En la presente descripción se proporcionan células asesinas naturales modificadas genéticamente que se modificaron para expresar los receptores de antígenos quiméricos (CAR). Las células contienen opcionalmente otras modificaciones que mejoran la citotoxicidad específica del tumor y la migración dirigida a los sitios del tumor. Además se contemplan métodos para usar las células asesinas naturales modificadas genéticamente para tratar pacientes con cáncer.