CELL CULTIVATION DEVICE FOR IN VITRO EVALUATION OF THE CYTOTOXICITY OF MATERIALS IN REAL DIRECT CONTACT

The present invention relates to a device that emulates a culture well, allowing cells to be cultured within samples, facilitates real direct contact, and simulates the in vitro microenvironment to which the cells will be exposed. Said device performs cytotoxicity, proliferation, and/or cell adhesio...

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Bibliographische Detailangaben
Hauptverfasser:	TORRES AVILA Itzel Pamela, RAMÍREZ SOTELO María Guadalupe, CHINO ULLOA Alexis, CASTREJÓN FLORES José Luis, ACERO PÉREZ María Del Carmen, HERNÁNDEZ SÁNCHEZ Enrique
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a device that emulates a culture well, allowing cells to be cultured within samples, facilitates real direct contact, and simulates the in vitro microenvironment to which the cells will be exposed. Said device performs cytotoxicity, proliferation, and/or cell adhesion tests within it, avoiding removing the samples or cells. Also, it is removable giving it the versatility to be attached to the culture base (8) and even the cell containment barrier (9) to different microscopy and characterization techniques, allowing obtaining results from the interaction of the cells with it or the materials evaluated. La presente invención es un dispositivo que emula un pozo de cultivo, permitiendo a las células estar cultivadas dentro de las muestras, facilita un contacto directo real y simula el microambiente in vitro al cual las células serán expuestas. Este dispositivo puede ser empleado para realizar ensayos de citotoxicidad, proliferación y/o adhesión celular dentro del mismo sin necesidad de remover las muestras o las células. Asimismo, es desmontable dándole la versatilidad para ser acoplada la base de cultivo (8) e incluso la barrera de contención celular (9) a diferentes técnicas de microscopía y de caracterización que permiten obtener resultados de la interacción de las células con él o los materiales que se van a evaluar.