SUBSTITUTED PYRROLIDINES AND THEIR USE IN THE TREATMENT OF CYSTIC FIIBROSIS

The invention discloses compounds of Formula (I), wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and meth...

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Bibliographische Detailangaben
Hauptverfasser:	Nicolas DESROY, Andrew BOGDAN, Robert J. ALTENBACH, Elsa DE LEMOS, Gregory A. GFESSER, Stephen N. GRESZLER, Xueqing WANG, Sylvain COUTY, Gang ZHAO, John R. KOENIG, Marc J. SCANIO, Xenia SEARLE, Bo LIU, Philip R. KYM, Christopher Gaëtan HOUSSEMAN, Ming C. YEUNG, Béranger DUTHION
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses compounds of Formula (I), wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention. La invención desvela compuestos de formula (I) Ver formula: En donde R1, R2, R2A, R3, R3A, R4 Y R5 son como se definen en el presente documento. La presente invención se refiere a compuestos y su uso en el tratamiento de la fibrosis quística, métodos para su producción, composiciones farmacéuticas que los contienen y métodos de tratamiento de la fibrosis quística administrando un compuesto de la invención.