GENETICALLY ENGINEERED CELLS AND METHODS OF MAKING THE SAME

GENETICALLY ENGINEERED CELLS AND METHODS OF MAKING THE SAME

Provided are CRIS PR/CAS -related methods, compositions and components for editing a target nucleic acid sequence, or modulating expression of a target nucleic acid sequence, and applications thereof in connection with cancer immunotherapy comprising adoptive transfer of engineered T cells or T cell...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: David A. BUMCROT, Jon JONES, Eugenio Marco RUBIO, Blythe SATHER, Ari E. FRIEDLAND, G. Grant WELSTEAD, Chris NYE, Ruth SALMON, Morgan L. MAEDER
Format: Patent
Sprache:eng ; spa
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Provided are CRIS PR/CAS -related methods, compositions and components for editing a target nucleic acid sequence, or modulating expression of a target nucleic acid sequence, and applications thereof in connection with cancer immunotherapy comprising adoptive transfer of engineered T cells or T cell precursors. Se proporcionan métodos, composiciones y componentes relacionados con CRISPR/CAS para editar una secuencia de ácido nucleico diana, o modular la expresión de una secuencia de ácido nucleico diana, y sus aplicaciones en relación con la inmunoterapia contra el cáncer que comprende transferencia adoptiva de linfocitos T modificados genéticamente o precursores de linfocitos T.