DECELLULARISED CELL WALL STRUCTURES FROM PLANTS AND FUNGUS AND USE THEREOF AS SCAFFOLD MATERIALS

Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for prepar...

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Bibliographische Detailangaben
Hauptverfasser: Andrew Edward PELLING, Charles Michel CUERRIER, Ryan Joseph HICKEY, Daniel J. MODULEVSKY
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described. En la presente divulgación se proporciona biomateriales de andamiaje que comprenden un tejido vegetal o fúngico descelularizado del que son retirados los materiales celulares y ácidos nucleicos del tejido, el tejido vegetal o fúngico descelularizado comprende una estructura porosa tridimensional a base de celulosa o quitina; también se proporcionan los métodos para preparar tales materiales de andamiaje, así como los usos de los mismos como un andamio implantable para soportar el crecimiento celular animal, para promover la regeneración tisular, para promover la angiogénesis, para un procedimiento de reemplazo de tejidos y/o como un implante celular para cirugía; adicionalmente se describe el tratamiento terapéutico y/o los métodos cosméticos que emplean tales andamiajes.