ANGIOTENSIN II RECEPTOR ANTAGONIST METABOLITE AND NEP INHIBITOR COMPOSITE, AND PREPARATION METHOD THEREOF

Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for prepa...

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Hauptverfasser: Song LI, Wenjie XU, Yang WANG, Yanxin ZHENG, Jie YAN, Jianqiong ZHI
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creator Song LI
Wenjie XU
Yang WANG
Yanxin ZHENG
Jie YAN
Jianqiong ZHI
description Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for preparing a pharmaceutical product for treating heart failure. En esta invención se proporcionan una serie de complejos supermoleculares (compuestos) con doble acción que están compuestos por el compuesto con efecto bloqueante del receptor de angiotensina II (AT1), inhibidor de neprilisina (NEPi) y sus cationes farmacéuticamente aceptables.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANGIOTENSIN II RECEPTOR ANTAGONIST METABOLITE AND NEP INHIBITOR COMPOSITE, AND PREPARATION METHOD THEREOF
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