ANGIOTENSIN II RECEPTOR ANTAGONIST METABOLITE AND NEP INHIBITOR COMPOSITE, AND PREPARATION METHOD THEREOF

Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for prepa...

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Bibliographische Detailangaben
Hauptverfasser:	Song LI, Wenjie XU, Yang WANG, Yanxin ZHENG, Jie YAN, Jianqiong ZHI
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for preparing a pharmaceutical product for treating heart failure. En esta invención se proporcionan una serie de complejos supermoleculares (compuestos) con doble acción que están compuestos por el compuesto con efecto bloqueante del receptor de angiotensina II (AT1), inhibidor de neprilisina (NEPi) y sus cationes farmacéuticamente aceptables.