INHIBITORS OF THE MENIN-MLL INTERACTION

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction. La presente invención se dirige a inhibido...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ZANG, Linghang, Chengguo DONG, CLAREMON, David A, VENKATRAMAN, Shankar, Suresh B. SINGH, Lanqi JIA, Yi FAN, ZHENG, Yajun, YUAN, Jing
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction. La presente invención se dirige a inhibidores de la interacción de menina con MLL y proteínas de fusión de MLL, composiciones farmacéuticas que contienen los mismos, y su uso en el tratamiento de cáncer y otras enfermedades mediante por la interacción de menina-MML.