METHODS AND INTERMEDIATES FOR THE PREPARATION BILE ACID DERIVATIVES

The present invention relates to methods and novel intermediates useful in the preparation of a compound or a pharmaceutically acceptable salt thereof. An objective of the present invention is to provide methods of preparing bile acid derivatives and novel intermediates. A use of the methods and intermediates described relates to the synthesis of bile acid derivatives which activate both FXR and TGR5. La presente invenci6n se refiere a métodos e intermedios novedosos útiles en la preparación de un compuesto o una sal farmacéuticamente aceptable del mismo. Un objetivo de la presente invención es proporcionar métodos para preparar derivados de ácidos biliares e intermedios novedosos. Un use de los métodos e intermedios descritos se refiere a la síntesis de derivados de ácidos biliares que activan tanto FXR como TGR5.