INHIBITORS OF EZH2

The present invention relates to compounds that inhibit activity of the histone lysine methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors. La presente in...

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Bibliographische Detailangaben
Hauptverfasser:	Anh- Quan Hannah NGUYEN, Miriam Filadelfa DEL PRADO, Michael John RODRIGUEZ, Mary Margaret MADER, Steban DOMINGUEZ, Yvonne Yee Mai YIP, Michael Enrico RICHETT, Kuo- Long YU, Deqi GUO
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds that inhibit activity of the histone lysine methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors. La presente invención se refiere a compuestos que inhiben la actividad de la histona lisina metiltransferasa, potenciador del homólogo Zeste 2 (EZH2, por sus siglas en inglés), composiciones farmacéuticas que comprenden los compuestos y métodos para usar los compuestos para tratar cáncer, tales como tumores hematológicos y sólidos.