APTAMERS SPECIFIC FOR TLR-4 AND USES THEREOF

The invention relates to a nucleic acid aptamer with the capability of binding specifically to and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and...

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Bibliographische Detailangaben
Hauptverfasser:	María Ángeles MORO SÁNCHEZ, Víctor Manuel GONZÁLEZ MUÑOZ, Gerónimo FERNÁNDEZ GÓMEZACÓN, Ignacio LIZASOAIN HERNÁNDEZ, Ana MORAGA YÉBENES, Mª Elena MARTÍN PALMA
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a nucleic acid aptamer with the capability of binding specifically to and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and to uses and methods for inhibiting TLR-4. Finally, the invention also relates to an aptamer for use in manufacturing a drug for the treatment of a pathology characterized by an increase in expression of TLR4 and/or an increase in activation of TLR-4. La invención se relaciona con un ácido nucleico aptámero con la capacidad de unirse específicamente e inhibir TLR-4, a un complex que comprenda dicho aptámero y un grupo funcional, así como a las composiciones farmacéuticas derivadas de ellos. La invención también se relaciona con los usos y métodos para inhibir TLR-4. Finalmente, la invención también se relaciona con un aptámero para uso en la manufactura de un fármaco para el tratamiento de una patología caracterizada por un aumento en la expresión de TLR-4 y/o un aumento en la activación de TLR-4.