SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukernias and solid tumors, in mammals, especially humans. Un compuesto con la fórmula (I) o uno de sus estereoisómeros, isómeros geométricos, tautómeros, N-óxidos, hidratos, solvatos, metabolitos, sales farmacéuticamente aceptables o profármacos, que se puede usar para tratar infección por HCV o un trastorno por HCV. También composiciones farmacéuticas que comprenden los compuestos revelados en la presente,que se pueden usar para tratar una infección por HCV o un trastorno por HCV.