QUINOLINE AND QUINAZOLINE AMIDES AS MODULATORS OF SODIUM CHANNELS

QUINOLINE AND QUINAZOLINE AMIDES AS MODULATORS OF SODIUM CHANNELS

The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: formula (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SARA SABINA HADIDA-RUAH, ANDREAS P. TERMIN, IULIANA LUCI ASGIAN, BRIAN RICHARD BEAR, JAMES PHILIP JOHNSON JR, VIJAYALAKSMI ARUMUGAM, COREY ANDERSON
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: formula (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. La invención se relaciona con compuestos de fórmula (I) o sales farmacéuticamente aceptables de los mismos, útiles como inhibidores de los canales de sodio: (ver Fórmula) La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos de uso de las composiciones en el tratamiento de varios trastornos, incluyendo el dolor.