PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY

This invention relates to novel pharmaceutical compositions comprising a therapeutica11y effective combination of a dopaminergic stabilizer known as Pridopidine, and an inhibitor of the vesicular monoamine transporter type 2 (VMAT) known as Tetrabenazine. The pharmaceutical compositions for use acco...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: EVA SUSANNA WATERS, ROSS NICHOLAS WATERS
Format: Patent
Sprache:eng ; spa
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Beschreibung
Zusammenfassung:This invention relates to novel pharmaceutical compositions comprising a therapeutica11y effective combination of a dopaminergic stabilizer known as Pridopidine, and an inhibitor of the vesicular monoamine transporter type 2 (VMAT) known as Tetrabenazine. The pharmaceutical compositions for use according- to the invention are contemplated particularly useful for improving the symptomatic therapeutic effects, and for reducing the adverse effects, of Tetrabenazine in the treatment of movement disorders, and in particular movement disorders associated with Huntington's disease, Gilles de la Tourette's syndrome, or tardive dyskinesia. Esta invención se refiere a composiciones farmacéuticas novedosas que comprenden una combinación terapéuticamente efectiva de un estabilizador dopaminérgico conocido como Pridopidina, y un inhibidor del transportador de monoamina vesicular (VMAT) tipo 2 conocido como Tetrabenazina. Las composiciones farmacéuticas para el uso con la invención se contemplan particularmente útiles para mejorar los efectos terapéuticos sintomáticos, y pare reducir los efectos adversos, de la Tetrabenazina en el tratamiento de trastornos de movimiento, y en particular trastornos de movimientos asociados con enfermedad de Huntington, síndrome de Gilles de la Tourette o discinesia tardía.