FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment...

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Hauptverfasser: VOLKER SCHELLENBERGER, FATBARDHA VARFAJ, JOHN KULMAN, PEI-YUN CHANG, CHIA-WEI WANG, TONGYAO LIU, JOSHUA SILVERMAN, BENJAMIN SPINK, NATHAN GEETHING, DEPING WANG, HAIYAN JIANG, ROBERT PETERS, WILLEM P. STEMMER, BAISONG MEI, SHENG DING, GARABET G. TOBY
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor Vlll-related diseases, disorders, and conditions. La presente invención se refiere a composiciones que comprenden factores de coagulación factor VIII unidos a polipéptido recombinante extendido (XTEN), ácidos nucleicos aislados que codifican las composiciones y vectores y células hospedadoras que contienen las mismas, y métodos para realizar y usar tales composiciones en el tratamiento de enfermedades, trastornos y afecciones relacionadas con el factor VIII.