METHOD FOR PREDICTING RISK OF HYPERTENSION ASSOCIATED WITH ANTI-ANGIOGENESIS THERAPY

The invention is concerned with a method of predicting a patient's susceptibility to developing hypertension associated with an anti-angiogenesis treatment, such as bevacizumab, by determing the genotype of KDR gene and/or EGF gene. The invention further relates to a pharmaceutical composition...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PAUL DELMAR, DIETHER LAMBRECHTS, STEFAN SCHERER, SANNE LYSBET DE HAAS
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The invention is concerned with a method of predicting a patient's susceptibility to developing hypertension associated with an anti-angiogenesis treatment, such as bevacizumab, by determing the genotype of KDR gene and/or EGF gene. The invention further relates to a pharmaceutical composition comprising an angiogenesis inhibitor, such as bevacizumab, for the treatment of a patient suffering from cancer based on the genotype of KDR gene and/or EGF. The invention further relates to a method for reducing the risk of hypertension associated with an anti-angiogenesis therapy, such as bevacizumab, in a patient suffering from cancer by determining the genotype of KDR gene and/or EGF gene. La invención se refiere a un método de predicción de la susceptibilidad de un paciente a desarrollar hipertensión asociada a un tratamiento antiangiogénesis, tal como bevacizumab, mediante la determinación del genotipo del gen KDR y/o del gen EGF. La invención se refiere además a una composición farmacéutica que comprende un inhibidor de la angiogénesis, tal como bevacizumab, para el tratamiento de un paciente que sufre de un cáncer, basado en el genotipo del gen KDR y/o EGF. La invención se refiere además a un método para reducir el riesgo de hipertensión asociado a una terapia antiangiogénesis, tal como bevacizumab, en un paciente que sufre de cáncer, mediante la determinación del genotipo del gen KDR y/o del gen EGF.