HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE WITH ENHANCED ACETATE AND SUCCINATE SUBSTITUTION

Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low- solubility active agent and such polymers, the polymers provide increas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	DANIEL E. DOBRY, WARREN K. MILLER, DAVID K. LYON, DWAYNE T. FRIESEN, WILLIAM B. CALDWELL, DAVID T. VODAK
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low- solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent. Se describen polímeros de acetato succinato de hidroxipropil metil celulosa (HPMCAS) con grados únicos de substitución de grupos hidroxipropoxi, metoxi, acetilo y succinoilo. Cuando se usan para hacer composiciones comprendiendo un agente activo de baja solubilidad y tales polímeros, los polímeros proporcionan concentraciones acuosas incrementadas y/o estabilidad físiça mejorada del agente activo.