SOLID COMPOSITIONS

The present invention features solid compositions comprising Compound IA, IB, IC or ID, or a pharmaceutically acceptable salt thereof, in an amorphous form. In one embodiment, Compound IA, IB, IC or ID, or a pharmaceutically acceptable salt thereof, is formulated in an amorphous solid dispersion whi...

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Bibliographische Detailangaben
Hauptverfasser: TANJA HEITERMANN, PETER HOLIG, JIANWEI WU, BRYAN K. ERICKSON, TINA JUNG, GERD WOEHRLE, NANCY E. SEVER, JUSTIN LAFOUNTAINE, ULRICH WESTDT, BERND LIEPOLD, BRENT D. SINCLAIR, SIMON KULLMANN, RENATO KOENIG, YI GAO, MIRKO PAULI, MADLEN THIEL, RUDOLF SCHROEDER
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present invention features solid compositions comprising Compound IA, IB, IC or ID, or a pharmaceutically acceptable salt thereof, in an amorphous form. In one embodiment, Compound IA, IB, IC or ID, or a pharmaceutically acceptable salt thereof, is formulated in an amorphous solid dispersion which comprises a pharmaceutically acceptable hydrophilic polymer and preferably a pharmaceutically acceptable surfactant. La presente invención, presenta composiciones sólidas que comprenden el Compuesto 1A, 1B, 1C y 1D o una sal farmacéuticamente aceptable de los mismos en una forma amorfa. En una modalidad el Compuesto 1A, 1B, 1C y 1D o una sal farmacéuticamente aceptable de los mismos, se formula en una dispersión sólida amorfa que comprende un polímero hidrofílico farmacéuticamente aceptable y preferentemente, un tensoactivo farmacéuticamente aceptable.