PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer. Se desvelan conjugados y compuestos para fabricar conjugados que son moléculas de PBD engarzad...

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Bibliographische Detailangaben
Hauptverfasser:	PAUL POLAKIS, LUKE MASTERSON, PHILIP WILSON HOWARD, SUSAN D. SPENCER, ANDREW POLSON, ARNAUD TIBERGHIEN, JOHN A. FLYGARE, HELGA E. RAAB, JANET L. GUNZNER
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer. Se desvelan conjugados y compuestos para fabricar conjugados que son moléculas de PBD engarzadas mediante la posición N10, junto con el uso de los conjugados para tratar enfermedades proliferativas, incluyendo cáncer.