Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, ZHUOZHI, GRUDZINSKA, JOANNA, TEBBE, JAN, BRUCKNER, SIMONE, PAN, JUNLIANG, BIRKENFELD, JOERG, WOBST, NINA, SCHOLZ, PETER, STENIG, SUSANNE, VOTSMEIER, CHRISTIAN
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided. Se proporcionan anticuerpos monoclonales aislados que se unen al inhibidor de la vía del factor tisular (TFPI) humano. También se contemplan las moléculas de ácido nucleico aisladas que codifican anticuerpos monoclonales que se unen al TFPI. También se proporcionan composiciones farmacéuticas que comprenden los anticuerpos monoclonales anti-TFPI y procedimientos de tratamiento de deficiencias o defectos en la coagulación mediante administración de los anticuerpos. También se proporcionan procedimientos para producir los anticuerpos.