DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES

A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, -OH, -O-C1-6 alkyl, =O, or halogen;R2 is hydrogen, C(O)OR8, C6H5C(O)OR8, (CH2)1-2OH, CR9R10OH, C(O)O(CH2)0-2 aryl, C(O)NR9R10, C(O)SO2NR9R10, C6H5OR9, W-C(O)OR8, W-OR9, Y, or P(O)(OR9)(ORlO); R3 is hydrogen or -C1-6 alkyl; R4 is hydrogen, -OH or -C(O)OR9; R5 is hydrogen or deuterium; R6 and R7 are independently-C1-6 alkyl, fluoro-substituted -C1-6 alkyl, deutero-substituted -C1-6 alkyl or -(CH2)1-2R11, wherein any carbon atom of the fluoro-substituted -C1-6 alkyl is mono- or di-substituted with fluoro, and any carbon atom of the deutero-substituted -C 1-6 alkyl is mono- or di-substituted with fluoro; R8, in each instance in which it occurs, is independently hydrogen, -C1-6 alkyl, or -(CH2)2N+(CH3) 3; R9 and R10, in each instance in which they occur, are independently -C1-6 alkyl; R11 is -OH, -O-C 1-6 alkyl, -0CD3, -OC(O)OC 1-6 alkyl, -NH2, -C6H5, -N3, or W; W is an unsubslituted 5- or 6-raembered heteroaryl ring having 1, 2, or 3 nitrogen atoms, or a substituted 5- or 6-membered heteroaryl ring having 1, 2, or 3 nitrogen atoms that is mono- or di-substituted at any carbon atom with R6 or R7; Y is a 5- or 6-membered heterocyclic ring having 1, 2, 3 or 4 heteroatoms which are N, O or S or stereoisomers thereof, or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable salts of stereoisomers thereof, and methods of using the compounds for treating hypertension. Un compuesto que tiene la estructura (Ver Formula) o una sal farmacéuticamente aceptable del mismo, en donde R1 es hidrógeno, -OH, -O-alquilo de C1-6 , =O, o halógeno; R2 es hidrógeno, -C(O)0R8, -C6H5C(O)OR8, -(CH2)1-20H, -CR9R10OH, -C(O)O(CH2)0-2 arilo, -C(O)NR9R10, -C(O)S02NR9R10, -C6H50R9, -W-C(O)0R8, -W-OR9,-Y, o -P(O)(0R9)(0R10); R3 es hidrógeno o -alquilo de C1-6; R4 es hidrógeno, -OH, o -C(O)0R9 R5 es hidrógeno o deuterio; R6 y R7 son independientemente -alquilo de C1-6, -alquilo de C1-6 fluoro sustituido, -alquilo de C1-6 deutero sustituido o -(CH2)1-2R11 , en donde cualquier átomo de carbono del -alquilo de C1-6 fluoro sustituido es mono o disustituido con fluoro, y cualquier átomo de carbono del -alquilo de C1-6 deutero sustituido es mono o disustituido con fluoro; R8, en cada ocasión que aparece, es independientemente hidrógeno, - alquilo de C1-6 o -(CH2)2N+(CH3)3 R9 y R10, en cada ocasión en que aparecen, son independientemente -alquilo de C1-6 R11 es -OH, -0-alquilo de