STABILISING EXCIPIENT FOR INACTIVATED WHOLE-VIRUS VACCINES

The invention relates to a vaccine composition containing: (a) inactivated whole virus; and (b) a stabilising excipient comprising (i) a buffer solution, (ii) a mixture of essential and non-essential amino acids, (iii) a disaccharide, (iv) a polyol, (v) a chelating agent, (vi) urea or a urea derivat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ALAIN FRANCON, ERIC CALVOSA, NADEGE MORENO, VIRGINIE FABRE, MICHEL CHEVALIER, SANDRINE CIGARIRNI
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention relates to a vaccine composition containing: (a) inactivated whole virus; and (b) a stabilising excipient comprising (i) a buffer solution, (ii) a mixture of essential and non-essential amino acids, (iii) a disaccharide, (iv) a polyol, (v) a chelating agent, (vi) urea or a urea derivative, and (vii) a non-ionic surfactant. La invención se relaciona a una composición de vacuna que contiene: (a) virus entero inactivado; y (b) un excipiente estabilizante que comprende (i) una solución reguladora, (ii) una mezcla de aminoácidos esenciales y no esenciales, (iii) un disacárido, (iv) un poliol, (v) un agente quelante, (vi) urea o un derivado de urea y (vii) un surfactante no iónico.