FLUOROQUINOLONE CARBOXYLIC ACID MOLECULAR CRYSTALS

FLUOROQUINOLONE CARBOXYLIC ACID MOLECULAR CRYSTALS

A molecular crystal form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-lH- azepin-l-yl)-l,4-dihydro-4-oxoquinoline-3-carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction ("XRPD") spectrum that comprises peaks at 2Î~ angles of 10.6, 15, 19.7, 21.1, and 22 ° ±...

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Bibliographische Detailangaben
1. Verfasser: HARRY M. KING, JR
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A molecular crystal form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-lH- azepin-l-yl)-l,4-dihydro-4-oxoquinoline-3-carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction ("XRPD") spectrum that comprises peaks at 2Î~ angles of 10.6, 15, 19.7, 21.1, and 22 ° ±0.2 °; (b) a DSC melting peak at 288 °C; (c) a 13C NMR spectrum having peaks at 23.3, 27.7, 41.1, 54.5, 116.6, and 153.5 ppm; and (d) pKa values of 5.65 and 9.91. Una forma de cristal molecular de ácido (R)-(+)-7-(3- amino-2,3,4,5,6,7-hexahidro-1H-azepin-1-il)-8-cloro-1- ciclopropil-6-fluoro-1, 4-dihidro-4-oxoquinolina-3-carboxílico es caracterizada por al menos uno de: (a) un espectro de difracción de polvo rayos X ("XRPD") que comprende picos en ángulos 2? de 10.6, 15, 19.7, 21.1, y 22° ± 0.2°; (b) un pico de fusión de DSC a 288°C; (c) un espectro 13C NMR que tiene picos en 23.3, 27.7, 41.1, 54.5, 116.6, y 153.5 ppm; y (d) valores de pKa de 5.65 y 9.91.