FEED SUPPLEMENT FOR MAMMALIAN CELL CULTURE AND METHODS OF USE

An improved feed supplement for culture of mammalian cells used to produce proteins is provided. The improved supplement is devoid of animal-derived components and protein hydrolysates. The invention also provides methods of using the supplement in production of a therapeutic proteins, such as an an...

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Bibliographische Detailangaben
Hauptverfasser:	MANAHAN, MATTHEW S, LING, WAI LAM WONG, OUYANG, ANLI
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An improved feed supplement for culture of mammalian cells used to produce proteins is provided. The improved supplement is devoid of animal-derived components and protein hydrolysates. The invention also provides methods of using the supplement in production of a therapeutic proteins, such as an antibody. In some embodiments, the antibody is an anti-human IL-23p19 antibody. Se provee un suplemento alimenticio mejorado para cultivo de las células de mamífero utilizado para producir proteínas; el suplemento mejorado carece de componentes derivados de animal e hidrolizados de proteína; la invención también provee métodos para el uso del suplemento en la producción de una proteína terapéutica, tal como un anticuerpo; en algunas modalidades, el anticuerpo es un anticuerpo anti-lL23p19 de humano.