A PRE-FILLED CONTAINER INSERT FOR MIXING TWO OR MORE INGREDIENTS FOR USE IN A PHARMACEUTICAL CONTAINER SYSTEM

The present invention relates to pharmaceutical container systems (21), and to pre-filled container inserts (17) for use therein, for mixing two or more ingredients (8) of a pharmaceutical product. The pre-filled container insert (17) of one embodiment comprises a moulded container casing (1) having walls (2), a bottom (3) and an open top (4) for receiving a solid component (8), a resilient stopper (9) for sealing the open top (4) of the moulded container casing (1), and a bottom disc (3) formed by a weakening rim (5) in the bottom periphery of the moulded container casing (1). The bottom disc (3) is openable to allow mixing of the pre-filled solid component (8) with a diluents fluid of the pharmaceutical container system (21) by introducing a spike (20) through the resilient stopper (9) applying a pushing force on the bottom disc (3), by which force the weakening rim (5) is broken and the container (17) is opened. The pre-filled container insert (17) of a further embodiment comprises a moulded container casing (1) having walls (2), a bottom (3) and an open top (4) for receiving an inner open cylinder (30) and a solid component (8), a resilient stopper (9) for sealing the open top (4) of the moulded container casing (1), and a bottom disc (3) formed by a weakening rim (5) in the bottom periphery of the moulded container casing (1). The bottom disc (3) is openable to allow mixing of the pre- filled solid component (8) with a diluents fluid of the pharmaceutical container system (21) by applying a pushing force onto the top of the moulded container compressing the casing (1) and forcing the inner cylinder (30) to push on the bottom disc (3), by which force the weakening rim (5) is broken and the container insert (17) is opened. La presente invención se refiere a un sistema de envase farmacéutico (21), y a inserciones de envases cargados previamente (17) para utilizar en este, a los efectos de mezclar dos o más ingredientes (8) de un producto farmacéutico. La inserción de encase cargado previamente (17) de una modalidad comprende una carcasa del envase moldeado (1) que tiene paredes (2), un fondo (3) y una tapa abierta (4) para recibir un componente sólido (8), un tapón flexible (9) para sellar la tapa abierta (4) de la carcasa del envase moldeado (1) y un disco inferior (3) formado por un reborde de debilitamiento (5) en la periferia del fondo de la carcasa del envase moldeado (1). El disco inferior (3) se puede abrir para permitir que se mezcle el component