N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RAMESH KAUL, YUANXI ZHOU, YANBING DING, MIKE GRIMWOOD, HASSAN PAJOUHESH, LINGYUN ZHANG, JASON TAN, YONGBAO ZHU, NAGASREE CHAKKA
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity, are disclosed Specifically, a series of compounds which are N-piperidinyl acetamide derivatives as shown in formula (1) are disclosed as calcium ion channel activating modulators Compositions comprising these compounds and the use of these compounds in the treatment or prevention of conditions such as obesity are also disclosed. Métodos y compuestos efectivos para mejorar condiciones caracterizadas por actividad no deseada de canal de calcio, particularmente actividad no deseada de canal de calcio tipo T, se divulga. Específicamente, una serie de compuestos que son derivados de N-piperidimil acetamida como se muestran en la fórmula (1) se divulgan como moduladores de activación de canal de iones de calcio. Composiciones que comprenden estos compuestos y el uso de estos compuestos en el tratamiento o prevención de condiciones tales como obesidad también se divulgan.